Professor James Murray begins work compiling words for the first edition of the Oxford English Dictionary in the mid-19th century, and receives over 10,000 entries from a patient at Broadmoor Criminal Lunatic Asylum, Dr. William Minor.

In the god-forsaken district of early-1860s Lower Manhattan known as the Five Points, the vicious Nativist, Bill "The Butcher" Cutting, is the supreme overlord of an area riddled with crime, prostitution, theft and murder, as the American Civil War still rages on. Sixteen whole years after the brutal murder of his father from Bill's blood-stained hands, an orphaned Irish-American, Amsterdam Vallon, returns to this melting pot of corruption to avenge his untimely death; however, a lot has changed since then. Who can remember the once-innocent boy and now a young man bent on revenge, who works his way up to the hierarchy of Five Points? Will Amsterdam ever taste the dangerous but sweet fruit of retribution?

In the god-forsaken district of early-1860s Lower Manhattan known as the Five Points, the vicious Nativist, Bill "The Butcher" Cutting, is the supreme overlord of an area riddled with crime, prostitution, theft and murder, as the American Civil War still rages on. Sixteen whole years after the brutal murder of his father from Bill's blood-stained hands, an orphaned Irish-American, Amsterdam Vallon, returns to this melting pot of corruption to avenge his untimely death; however, a lot has changed since then. Who can remember the once-innocent boy and now a young man bent on revenge, who works his way up to the hierarchy of Five Points? Will Amsterdam ever taste the dangerous but sweet fruit of retribution?

The crown jewel of Her Majesty's Secret Intelligence Service, Agent Lorraine Broughton (Theron) is equal parts spycraft, sensuality and savagery, willing to deploy any of her skills to stay alive on her impossible mission. Sent alone into Berlin to deliver a priceless dossier out of the destabilized city, she partners with embedded station chief David Percival (James McAvoy) to navigate her way through the deadliest game of spies.